Pall Upstream Solutions
 
Pall Corporation has been a trusted name for over 60 years and is a global supplier of cell culture technology for upstream processing needs in biopharmaceutical markets.

Beyond our compelling track record and proven reliability, we have an industry-leading engineering team dedicated to the development of robust, affordable biopharmaceutical solutions, and a global structure to mitigate risk and support our customers’ regulatory compliance. Pall technologies deliver improved cell culture system output, higher expressed titers and optimized timelines for scale-up through commercialization.
High Performance Suspension
Cell Culture Solutions
Pall’s rocking and stirred tank bioreactor platforms have many unique design features for excellent and robust performance. In addition they are reliable and easy to use, resulting in high process safety and product quality.

  • The Allegro™ XRS platform rotates on 2 axes to provide excellent mixing and mass transfer.
  • The Allegro STR bioreactor builds on a square biocontainer shape, to optimize mixing with natural baffling, in a compact footprint.
  • The PadReactor® stirred tank reactor also features a square biocontainer design to achieve optimal mixing results, with a paddle mixer to give high performance for shear-sensitive cells.
  • For process development and high throughput screening of media or cell lines, the Micro24 microreactor allows users to simultaneously run 24 small independent experiments.
Adherent Cell
Culture Solutions
Adherent cell growth offers a number of challenges that has driven many users to search for a suspension culture alternative, not always with success.

Pall has focussed its efforts on the development of solutions for adherent cell growth that allow for:

  • Reduced footprint and less operator intervention vs roller bottle or cell stack solutions
  • Automation and control for better process robustness, and compliance with regulatory standards
  • Simplicity and economics – reduction of seed train and scale-up efforts
Our offering includes:

Single-Use
Upstream Solutions
The Allegro™ system platform from Pall is a comprehensive program providing processing solutions, technical support and validation for single-use systems. Our Allegro single-use systems incorporate state-of-the art Pall technologies as well as qualified, externally-sourced products. All systems are supplied fully documented.

Pall's comprehensive range of scalable single-use products enables you to use state-of-the-art single-use systems from small-scale development work to full-scale manufacturing.
Features

  • Flexible design — systems can be custom- designed, to ensure you get the optimal solution
  • Flexible size — scalable, so systems can easily be modified, with minimal revalidation
  • Flexible support — we can assist with validation studies, regulatory compliance, (FAT) Factory Acceptance Tests and (SAT) Site Acceptance Tests
Analytical Solutions from Upstream
Bioprocess to Manufacturing
Pall’s ForteBio Octet® and BLItz® systems offer rapid, simple and accurate determination of protein titer, contaminant detection and protein quality analysis, enabling utility throughout process development, quality control and manufacturing. Learn more about:

  • Rapid, automated, protein titer and quality analysis in cell line development and bioreactor monitoring
  • Host cell protein (HCP) and residual protein A contaminant detection assay kits
  • Quality control for release testing of biopharmaceuticals
Contact Us
A Pall upstream solutions specialist will contact you to discuss your application requirements